Aldactone (spironolactone) may cause decreased sex drive in 5% to 30% of people. This drug may also cause the following symptoms that are related to decreased sex drive:

* Impotence (inability to achieve an erection or to ejaculate) Impotence in 5% to 30% of people.

* Yellow highlights indicate symptoms related to decreased sex drive.

Endocrinologic side effects have been due to the antiandrogenic properties of spironolactone. Five percent to 30% of male patients complained of gynecomastia. Female patients reported hirsutism, oligomenorrhea, amenorrhea, menorrhagia, and breast tenderness. These side effects appeared to be dose related, and were more likely during long term therapy. Gynecomastia may be more likely in some male patients with liver disease due to the increased conversion of androgens to estrogens in severe liver disease.