Plavix (clopidogrel) cardiovascular medicine profile

Pharmaceutical name: Clopidogrel bisulfate

Substance: Clopidogrel [Ban:Inn]

Active ingredient: Clopidogrel hydrogen sulphate

Common brand, trade, commercial denominations: Plavix, Clopilet, Ceruvin, Iscover, Cloplat-75.

Manufacturers: Bristol-Myers Squibb, Sanofi-Aventis, Sun Pharmaceuticals, Ranbaxy Laboratories, Apotex Corp, Allscripts Healthcare Solutions, Cipla, Teva.

Systematic (IUPAC) name: (+)-(S)-methyl 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate

Molecular formula: C16H16ClNO2S

Molecular mass: 419.9 g/mol

Bioavailability: >50%

Protein binding: 94–98%

Half life: 7–8 hours (inactive metabolite)

Excretion: 50% renal, 46% biliary

CAS number: 113665-84-2

Pharmacologic class: platelet aggregation inhibitor

Therapeutic class: antiplatelet drug

Routes: oral