Clenbuterol info
Note:
In case that 20mcg tabs in strips are temporary off stock,
we ship another brand with double dosage 40mcg/tab in loose tabs, - no extra charge.
e.g. You ordered 2x20mcg Clebuterol, and the product went temporary out of stock during your order confirming and shipping office.
In that case you will receive 2x40mcg Clenbuterol (different brand), and profit double the dosage - no extra charge.
Thank you for understanding.
Clenbuterol
is a widely used bronchodilator in many parts of the world.
The drug is most often prepared in 20mcg tablets, but it
is also available in syrup and injectable form. Clenbuterol
belongs to a broad group of drugs knows as sympathomimetics.
These drugs affect that sympathetic nervous system in a
wide number of ways, largely mediated by the distribution
of adrenoceptors. There are actually nine different types
of these receptors in the body, which are classified as
either alpha or beta and further subcategorized by type
number. Depending on the specific affinities of these agents
for the various receptors, they can potentially be used
in the treatment of conditions such as asthma, hypertension,
cardiovascular shock, arrhythmias, migraine headaches and
anaphylactic shock. The text Goodman and Gillman's The Pharmacological
Basis of Therapeutics Edition does a good job of describing
the diverse nature in which these drugs affect the body:
`Most
of the actions of catecholamines and sympathomimetic agents
can be classified into seven broad types:
1.) peripheral excitatory action on certain types of smooth
muscles such as those in blood vessels supplying the skin,
kidney, and mucous membranes, and on the gland cells, such
as those of the salivary and sweat glands;
2.) a peripheral inhibitory action on certain other types
of smooth muscle, such as those in the wall of the gut,
in the bronchial tree, and in blood vessels supplying skeletal
muscle;
3.) a cardiac excitatory action, responsible for in increase
in heart rate and force of contraction;
4.) metabolic actions, such as an increase in the rate of
glycogenolysis in liver and muscle and liberation of free
fatty acids from adipose tissue;
5.) endocrine actions, such as modulation of the secretion
of insulin, rennin, and pituitary hormones;
6.) CNS actions, such as respiratory stimulation and, with
some of the drugs, an increase in wakefulness and psychomotor
activity and a reduction in appetite; and
7.) presynaptic actions that result in either inhibition
or facilitation of the release of the neurotransmitters
such as such as norepinephrine and acetylcholine."
The drug Clenbuterol
is specifically a selective beta-2 sympathomimetic, primarily
affecting only one of the three subsets of beta-receptors.
Of particular interest is the fact that this drug has little
beta-1 stimulating activity. Since beta-1 receptors are
closely tied to the cardiac effects of these agents, this
allows Clenbuterol to reduce reversible airway obstruction
(and effect of beta-2 stimulation) with much less cardiovascular
side effects compared to nonselective beta agonists. Clinical
studies with this drug show it is extremely effective as
a bronchodilator, with a low level of user complaints and
high patient compliance. Clenbuterol also exhibits an extremely
long half-life in the body, which is measured to be approximately
34 hours. This makes steady blood levels easy to achieve,
requiring only a single or twice daily dosing schedule at
most. This of course makes it much easier for the patient
to use, and may tie in to its high compliance rate. In spite
that Clenbuterol is available in a wide number of other
countries however; this compound has never been approved
for use in the United States. The fact that there are a
number of similar, effective asthma medications already
available in this country may have something to do with
this, as a prospective drug firm would likely not find it
a profitable enough product to warrant undergoing the expense
of the FDA approval process. Regardless, foreign Clenbuterol
preparations are widely available on the U.S. black market.
In animal studies,
Clenbuterol is shown to exhibit anabolic activity, so it
is obviously an attractive trait to the athlete. This compound
is additionally a known thermogenic, with beta-2 agonists
like Clenbuterol shown to directly stimulate fat cells and
accelerate the breakdown of triglycerides to form free fatty
acids. Its efficacy in this area makes Clenbuterol a very
attractive, and today almost mandatory, pre-contest drug.
Those interested in this drug are most often hoping it will
impart a little of both benefits, promoting the loss of
body fat while imparting strength and muscle mass increases.
But as was well pointed out by a review published in the
August 1995 issue of Medicine and Science in Sports and
Exercise, the possible anabolic activities in humans are
very questionable, and based only on animal data using much
larger doses than would be required for bronchodilation.
With such reports there has been a lot of debate lately
as to whether or not Clenbuterol is really anabolic at all.
Some seem to swear by the fact that it builds muscle regardless,
firmly sticking by "clen" as a great off-season
or adjunct anabolic. To others such reports are confirmation
that athletes have wasted valuable time and money on drugs
that do not work as they are intended to by the user. This
debate continues today, with many still using Clenbuterol
as a potential anabolic. With this in mind athletes will
tailor their dosage and cycling of this product individually
depending on which of the two "possible" results
are more desired, and how much side effects are to be tolerated.
The possible side effects of Clenbuterol include those of
other CNS stimulants, and include such occurrences as shaky
hands, insomnia, sweating, increased blood pressure and
nausea. These side effects will generally subside after
a week or so of use however, once the user becomes accustomed
to the drug. One would typically start a cycle by gradually
increasing the dosage each day until a desired range is
established. This process will minimize the unwanted side
effects seen from the drug; which otherwise might be dramatic
if a large dose is administered from the onset. Men generally
end up in the range of 2-8 tablets per day, although some
people do claim to tolerate even higher dosages. Women get
by on less, generally 2-4 tablets daily. Very quickly, the
drug will elevate the body temperature. The rise is not
usually dramatic, perhaps a half of a Cegree or so, sometimes
a little more. This elevation is due to your body burning
excess energy (largely from fat) and is usually not uncomfortable.
Now that it is working, the number of consecutive days Clenbuterol
can be used is believed to be dependent on the goal of the
individual. To be clear, the athletic benefits of this drug
will only last for a limited time and then diminish, largely
due to beta-receptor down regulation. When using it for
fat loss. the primary effect of the drug, it seems to work
well for approximately 4-6 weeks. During this period users
will want to constantly monitor their body temperature.
We are assured Clenbuterol is working by the temperature
elevation. Once the temperature drops back to normal, Clenbuterol
is no longer exhibiting a thermogenic effect. At this point
increasing the dosage would not be very effective, and a
break for at least a few weeks should be taken before it
is used again effectively. If one is looking for strength
gains, Clenbuterol appears to be effective for a much shorter
period of time, around 3-4 weeks. This may be due to an
absence of real anabolic effect, with the strength gain
seen with Clenbuterol possibly due only to the stimulant
properties of the drug (similar to the strength boost seen
by Ephedrine users). Again however, this is still debated.
Many competitors
also find the fat burning effect of Clenbuterol can be further
enhanced by additional substances. When combined with thyroid
hormones, specifically the powerful Cytomel®, the thermogenic
effect can become extremely dramatic. This can be to a point
that the athlete could shred exceptional amounts of extra
fat during contest preparations, without a dramatic restriction
in calories. Such a mix can be further used during a steroid
cycle, eliciting a much harder look from the anabolics.
These cutting agents can often greatly inhibit extra fat
storage during the cycle, even when using strong aromatizing
androgens. A Clenbuterol/thyroid mix is also common when
using growth hormone, further enhancing the thermogenic
and anabolic effect of this therapy.
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